Finished the riots against the feudalism the political of Sabaudi took over the and  in 1807 divided the island in 15 Prefectures; Serdiana entered in the Prefecture of Cagliari.           
 
The first years of the 800 were years of famine both because of the drought both because the few crops were destroyed by the animals to the wild state that, for lack of pastures, invaded the cultivated grounds.
In this period in Seriana spread also, the smallpox. The conditions of the inhabitants also worsened for the lack of drinkable water in the territory, whose provisioning depended on Sicci (Funtana de Coccu).
The Mayor emanated extraordinary provisions for the hygiene and, to face hunger problemr, and desposed the sale of the cheese in substitution of the bread.
To remember these awful years of famine, in particularly the year 1812, it's still used say in sardinan language “…e unu famini that him annu doxi “. (a famine of the year twelve)
 
In 1801, not being male heirs after the death of Don Efisio Luigi Carcassona, the feuds of Donori and Serdiana passed in inheritance to his daughter Francesca. She deceased after the birth of her first child in 1823, and left everything in inheritance to her sister Giovanna, that was the last Marquise of Serdiana and Donori.
 
In the years among 1828-1830 only few owners succeeded in drawing benefit from the law  “Law on the chiudende”, naturally those that  knew how to read and write had many servants”. This law allowed the owners to delimit the fields,  excluded those that constituted a place of passage or  were turned to pasture, or if  there were springs or drinking trough.
 
The 21 of may 1836, with the edict of the king Carlo Alberto, there was the abolition of the lord-like jurisdictions.  
 
In 1839 the feuds of Serdiana and Donori were ransomed from Giovanna Carcassona behind the concession of the Supreme Council of the Kingdom of Sardinia.
 
In the 1840 Serdiana became an autonomous Commune.
 
In the first census of the population of Sardinia, effected in 1842 for the king Carlo Alberto's will, Serdiana resulted to be among the 62 Communes of the Province of Cagliari and was inserted in the District of St. Pantaleo.
 
As it regards the origin of the name, the researchers are not in agreement. There is who hypothesizes a derivation from the fenicium root “SARED” that means red, from the color of the existing clays in the zone, there is instead who sustains that the ancient place-name would derive from “Sergius” a rich Roman patrician “cives”, whose agricultural possessions would have given origin to the first nucleus from which then the Town developed with the name of “Sergiana”.